Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer
نویسندگان
چکیده
From the Departments of Radiation Oncology (B.S., S.S.) and Pulmonary Diseases (P.P.), VU University Medical Center, Amsterdam; and Arnhem’s Radiotherapeutisch Instituut, Arnhem (G.K.) — both in the Netherlands; Christie Hospital, Manchester (C.F.-F.); University of Dundee Ninewells Hospital, Dundee (E.R.); Cookridge Hospital, Leeds (M.S.); and Weston Park Hospital, Sheffield (M.H.) — all in the United Kingdom; and the Departments of Statistics (L.C.) and Medical Research (E.M.), European Organisation for Research and Treatment of Cancer Data Center, Brussels. Address reprint requests to Dr. Slotman at the Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands, or at [email protected].
منابع مشابه
Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer.
abtract Purpose Extensive-stage small-cell lung cancer (esSCLC) is an incurable disease and represents a therapeutic challenge because of its poor prognosis. Studies in prophylactic cranial irradiation (PCI) in esSCLC have shown a decreased incidence of symptomatic brain metastases in patients who respond to systemic chemotherapy. However, its effect on overall survival is debatable. We evaluat...
متن کاملSCLC extensive disease – treatment guidance by extent or/and biology of response?
In extensive disease of small cell lung cancer a doubling of the one-year-survival rate was reported in August 2007 by prophylactic cranial irradiation applied to patients who experienced any response to initial chemotherapy. We discuss the treatment concept of extensive disease in the face of the latest results and older studies with additional thoracic irradiation in this subgroup. A randomiz...
متن کاملMetastasectomy of Solitary Adrenal Metastasis From Small Cell Lung Cancer
Most extensive-stage small cell lung cancers have disseminated disease at diagnosis, and solitary adrenal metastasis from small cell lung cancer is rare. We report the case of a 51-year-old man with extensive-stage small cell lung cancer with solitary right adrenal metastasis (T2N0M1), who was cured with resection of primary tumor, chemotherapy (cisplatin, etoposide), adrenalectomy, consolidati...
متن کاملProphylactic cranial irradiation in small-cell lung cancer: is it ever indicated?
Prophylactic cranial irradiation (PCI) is being reintroduced into multimodality treatment protocols of patients with small-cell lung cancer (SCLC). The history of its use brings interesting insights into clinical evaluations of treatment strategies and design of relevant and informative trials. The critical issues of effectiveness and overall health gains of prophylactic cranial irradiation hav...
متن کاملCurrent concepts in the management of small cell lung cancer
Small cell lung cancer (SCLC) has a clinical course that is distinct from its more common counterpart non-small cell lung cancer. SCLC continues to be a major clinical problem, with an aggressive clinical course and short disease-free duration after initial therapy. Current optimal treatment consists of chemotherapy with platinum-etoposide, given concurrently with thoracic irradiation in patien...
متن کاملTreatment of extensive-stage small cell lung carcinoma: current status and future prospects.
Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. Although SCLC is very chemoradiosensitive and high response rates are obtained with treatment, relapse rates are high and the prognosis remains very poor. In limited-stage SCLC, the overall survival rate has been ...
متن کامل